49ers RB Isaac Guerendo gets chance to start with injuries to McCaffrey, Mason
With Christian McCaffrey and Jordan Mason out with injuries for the San Francisco 49ers, Isaac Guerendo will step into a starting role Sunday.
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With Christian McCaffrey and Jordan Mason out with injuries for the San Francisco 49ers, Isaac Guerendo will step into a starting role Sunday.
San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as "potentially" season-ending in the 49ers' 35-10 loss to the Buffalo Bills on Sunday night.
Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills clinched their fifth straight AFC East title with a 35-10 victory over the San Francisco 49ers on a snowy Sunday night.
Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC champions sitting at 5-6.
Buffalo Bills coach Sean McDermott ruled out Dalton Kincaid from playing against San Francisco on Sunday night, while holding open the door for starting linebacker Matt Milano's return after missing nearly 14 months due to injuries.
Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an injury to his throwing shoulder.
John Madden's love of football and family came through the most on Thanksgiving, and his legacy will once again be honored this holiday.
Getting blown out in Green Bay following another squandered late lead the previous week against Seattle has quickly turned the San Francisco 49ers from a Super Bowl contender into a team just fighting to get back to the playoffs.
San Francisco quarterback Brock Purdy took part in some light throwing after missing his first career game due to an injury, and the 49ers are hoping he can return this week.
Filling in for the injured Brock Purdy, 32-year-old journeyman quarterback Brandon Allen didn't get nearly enough help from his more recognizable San Francisco 49ers teammates as he made his first start in nearly three years.
Josh Jacobs rushed for 106 yards and matched a career high with three touchdowns and the Green Bay Packers trounced the short-handed San Francisco 49ers 38-10.
San Francisco 49ers quarterback Brock Purdy will miss Sunday's game against the Green Bay Packers with a sore throwing shoulder.
The Green Bay Packers have lost to San Francisco in the playoffs three times in the last five seasons and wouldn't mind seeing the 49ers miss the postseason entirely.
The San Francisco 49ers are expecting to get star tight end George Kittle back this week for a key game against Green Bay but are uncertain whether top pass rusher Nick Bosa will be able to play.
The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to Seattle.
Geno Smith scored on a 13-yard scramble with 12 seconds remaining and the Seattle Seahawks snapped a six-game losing streak against the San Francisco 49ers with a 20-17 victory.
San Francisco 49ers tight end George Kittle will miss the game against the Seattle Seahawks with a hamstring injury.
The San Francisco 49ers are happy to return home to a cooler climate this week as they face off against division rivals the Seattle Seahawks at home on Sunday.
Deommodore Lenoir's NFL career didn't get off to the greatest starts when he accidentally posted an offseason practice video on social media that led to a fine for the San Francisco 49ers and coach Kyle Shanahan for violating rules about no contact in practice.
San Francisco 49ers coach Kyle Shanahan called a sideline spat involving star receiver Deebo Samuel and two teammates an "overreaction" and said the team has put it to rest.
San Francisco's star running back Christian McCaffery returned to the 49ers lineup for the first time this season after missing the first eight games, contributing to the team's 23-20 win over the Tampa Bay Buccaneers on Sunday.
Jake Moody redeemed himself after missing three earlier field goals by booting a 44-yarder as time expired to give the San Francisco 49ers a 23-20 victory over the Tampa Bay Buccaneers in running back Christian McCaffrey's season debut.
A person familiar with the matter says San Francisco 49ers star defensive end Nick Bosa has been fined by the NFL for wearing a hat with a pro-Donald Trump message during a postgame television interview.
While he is still officially listed as "questionable" for Sunday, it appears San Francisco 49ers All-Pro running back Christian McCaffrey will finally make his season debut against the Tampa Bay Buccaneers.
Both the San Francisco 49ers and the Tampa Bay Buccaneers are hoping to shrug off their so-so starts to kick off the second half of the NFL season with a win.
On Thursday night, the Golden State Valkyries became the first-ever franchise expansion team in WNBA history to make the playoffs in their inaugural season.
Bay Area scientists are creating baby corals to help regenerate the world's second-largest coral reef, which is being devastated by climate change.
President Trump will sign an executive order Friday directing the Department of Defense to use the name Department of War as a "secondary title" — restoring a name it last held in the late 1940s.
A shooting on Interstate Highway 880 in Oakland on Thursday afternoon injured a driver and led to the closure of all southbound lanes, authorities said.
All lanes of southbound Highway 17 in the Santa Cruz Mountains remain closed Thursday afternoon following an injury crash involving an overturned fuel tanker truck during the morning commute, officials said.
On Thursday night, the Golden State Valkyries became the first-ever franchise expansion team in WNBA history to make the playoffs in their inaugural season.
Bay Area scientists are creating baby corals to help regenerate the world's second-largest coral reef, which is being devastated by climate change.
A shooting on Interstate Highway 880 in Oakland on Thursday afternoon injured a driver and led to the closure of all southbound lanes, authorities said.
All lanes of southbound Highway 17 in the Santa Cruz Mountains remain closed Thursday afternoon following an injury crash involving an overturned fuel tanker truck during the morning commute, officials said.
A bill seeking to speed up a project to widen Highway 37 in the North Bay by waiving certain environmental rules is heading to Gov. Gavin Newsom's desk, after being approved by the legislature.
On Thursday night, the Golden State Valkyries became the first-ever franchise expansion team in WNBA history to make the playoffs in their inaugural season.
A man walking on the U.S. Highway 101 was shot by a San Francisco police officer Thursday after threatening the officer with an edged weapon, the department said.
It was the end of an era in Chinatown when restaurant Sam Wo shut its doors in January, but now, a group of local investors is determined to keep the legacy of Sam Wo going.
Golden State Valkyries fans could get the chance to see the team secure its playoff spot on Thursday at Balhalla as they face the Dallas Wings.
A Bay Area woman recieved a nearly $2,000 insurance claim denial from her maternity stay two years prior. Stunned, she decided to fight it and said, at one point, the bill even came back with her toddler's name on it. That's when she turned to AI.
A shooting on Interstate Highway 880 in Oakland on Thursday afternoon injured a driver and led to the closure of all southbound lanes, authorities said.
Police in Alameda seized slot machines, firearms and other items following a bust of an alleged gambling den that was operating inside a home, officers said.
Oakland police said a security guard shot at a group of armed robbers, who then fled the scene and crashed in Hayward.
A vacant Pleasant Hill lot is about to undergo a change, at least on paper. The city will be designating it as 'Multi-family, Medium density' to allow the same kind of housing, three-story townhouses, that already exists right across the street.
The Mexican National Soccer Team became the victims of a burglary in downtown Oakland this week. Early Monday morning, the team realized their truck had been broken into, and thousands of dollars' worth of equipment was stolen.
All lanes of southbound Highway 17 in the Santa Cruz Mountains remain closed Thursday afternoon following an injury crash involving an overturned fuel tanker truck during the morning commute, officials said.
Waymo self-driving robotaxis will soon shuttle passengers to San Jose Mineta International Airport after the company received authorization, airport officials announced Thursday.
Police in San Jose were seeking the public's help in finding suspects in a 2019 fatal stabbing and have released surveillance video in the hope of generating leads in the case.
Santa Clara police shot and killed a person suspected of stabbing another person inside a home on Wednesday morning, the department said.
San Jose Police said a cyclist was arrested on suspicion of DUI after crashing into a woman and seriously injuring her. She died days later from her injuries, police said.
A bill seeking to speed up a project to widen Highway 37 in the North Bay by waiving certain environmental rules is heading to Gov. Gavin Newsom's desk, after being approved by the legislature.
For the first time in its history, San Anselmo has instituted paid parking on its main commercial street. That, in itself, would be enough to make people angry, but it is the system they chose for payment that has a lot of people frustrated.
Authorities in Napa County announced that evacuation orders and warnings connected to the Pickett Fire have been lifted, as firefighters approach full containment.
Authorities in Marin County announced the arrest of a Peninsula man suspected of stealing a check worth more than $15,000 and depositing the funds into his account.
Fire crews were called to a fire on Dale Court just before 1:30 a.m. and arrived to find a double-wide mobile home on fire.
On Thursday night, the Golden State Valkyries became the first-ever franchise expansion team in WNBA history to make the playoffs in their inaugural season.
Matt Chapman hit two home runs after appealing a one-game suspension, and the San Francisco Giants beat the Colorado Rockies 10-8 on Wednesday night to finish a three-game sweep with their fourth straight victory.
Golden State Valkyries fans could get the chance to see the team secure its playoff spot on Thursday at Balhalla as they face the Dallas Wings.
The Mexican National Soccer Team became the victims of a burglary in downtown Oakland this week. Early Monday morning, the team realized their truck had been broken into, and thousands of dollars' worth of equipment was stolen.
Temi Fagbenle scored 16 points and the Golden State Valkyries beat the New York Liberty 66-58 for their fourth straight win to close in on becoming the first expansion team to earn a playoff berth in an inaugural season.
A shooting on Interstate Highway 880 in Oakland on Thursday afternoon injured a driver and led to the closure of all southbound lanes, authorities said.
All lanes of southbound Highway 17 in the Santa Cruz Mountains remain closed Thursday afternoon following an injury crash involving an overturned fuel tanker truck during the morning commute, officials said.
A man walking on the U.S. Highway 101 was shot by a San Francisco police officer Thursday after threatening the officer with an edged weapon, the department said.
Police in San Jose were seeking the public's help in finding suspects in a 2019 fatal stabbing and have released surveillance video in the hope of generating leads in the case.
Police in Alameda seized slot machines, firearms and other items following a bust of an alleged gambling den that was operating inside a home, officers said.
Waymo self-driving robotaxis will soon shuttle passengers to San Jose Mineta International Airport after the company received authorization, airport officials announced Thursday.
A Bay Area woman recieved a nearly $2,000 insurance claim denial from her maternity stay two years prior. Stunned, she decided to fight it and said, at one point, the bill even came back with her toddler's name on it. That's when she turned to AI.
For the first time in its history, San Anselmo has instituted paid parking on its main commercial street. That, in itself, would be enough to make people angry, but it is the system they chose for payment that has a lot of people frustrated.
Labor Day 2025 comes at a time of great uncertainty in the job market, especially in the high-paying white-collar sector. The threat is coming from artificial intelligence as companies look to be more efficient by employing fewer human workers. Now, it may be those working in blue-collar jobs who may be more resilient in an AI-driven world.
Stanford University research offers insights for students and young workers as artificial intelligence begins to reshape the labor market.
A Bay Area woman recieved a nearly $2,000 insurance claim denial from her maternity stay two years prior. Stunned, she decided to fight it and said, at one point, the bill even came back with her toddler's name on it. That's when she turned to AI.
California, Oregon, Washington and Hawaii announced the formation of a health alliance to guide residents on vaccines and immunizations because of what a joint statement called "the politicization of science" by the federal government.
About 42% of the children in the study diagnosed with ADHD were prescribed drugs within 30 days of diagnosis.
Public health officials said the person may have been bitten by an infected flea while camping in the South Lake Tahoe area.
The Contra Costa County Board of Supervisors on Tuesday appointed San Francisco's former public health director to oversee its own county health department.
President Trump will sign an executive order Friday directing the Department of Defense to use the name Department of War as a "secondary title" — restoring a name it last held in the late 1940s.
A bill seeking to speed up a project to widen Highway 37 in the North Bay by waiving certain environmental rules is heading to Gov. Gavin Newsom's desk, after being approved by the legislature.
Billionaire Elon Musk did not attend the dinner.
A vacant Pleasant Hill lot is about to undergo a change, at least on paper. The city will be designating it as 'Multi-family, Medium density' to allow the same kind of housing, three-story townhouses, that already exists right across the street.
Most Americans say prices are going up and expect them to keep going up.
A former Yosemite employee says they've been fired by the National Park Service, three months after flying a transgender pride flag from El Capitan.
For the past three years, LGBTQ+ youth could contact 988 and press 3 to connect them to a counselor specifically trained to support their mental health needs.
A Bay Area mother and her adult son are recalling with pride their family journey in a lesbian household that bucked traditional expectations of masculinity.
San Francisco International Airport has been declared among the world's "most beautiful" for its design of Harvey Milk Terminal 1, which was completed last year.
Hope, Love, Pride — A Celebration will showcase live reporting from the parade route, special guests in studio, and stories from throughout Pride month that feature people from the Bay Area's LGBTQ community.
On Thursday night, the Golden State Valkyries became the first-ever franchise expansion team in WNBA history to make the playoffs in their inaugural season.
Canadian First Nations actor Graham Greene died at 73 after a lengthy illness, his representative told CBS News.
The 58-year-old chef said in a social media post that he had a Basal cell carcinoma removed from his skin.
Taylor Swift and Travis Kelce announced the news of their engagement with photos on Instagram.
Around 5:50 a.m., LAPD officers responded to Ventura Boulevard and Vineland Avenue for a man walking in the street.
Ever since the COVID-19 pandemic, the Oakland Unified School District has seen an alarming spike in the number of unhoused students in the school system who deal with a host of challenges far beyond what most children face.
Meteorologist and CBS News Bay Area's resident pilot Lt. Jessica Burch got a treat during Fleet Week, taking to the skies with one of the Blue Angels.
A Bay Area man discovered his devastating loss left him with a new opportunity to rethink how he lives -- follow his journey in virtual reality, 360-degree video.
A groundbreaking medical study involving the UCSF Medical Center has shown some colorectal cancer patients can safely skip radiation treatment and enjoy a potentially higher quality of life.
Every day, San Francisco bar pilot Captain Zach Kellerman goes through what might just be the world's most dangerous commute.
Randi Seidner says as soon as she heard that the WNBA was expanding to the Bay Area, she knew she had to get season tickets.
Bay Area scientists are creating baby corals to help regenerate the world's second-largest coral reef, which is being devastated by climate change.
There was a debate over safety in Oakland Thursday as some residents debate if they're doing more harm then good.
The Golden State Valkyries are a win away from clinching a playoff spot in their inaugural season in the WNBA and the excitement surrounding the team is pervasive. Lauren Toms reports.
Boats anchored near the Jack London Aquatic Center in Oakland are violating an ordinance that bans anchoring for more than 12 hours, and the lack of enforcement is affecting high school rowing crews. Kevin Ko reports.
In 2025, KPIX is moving to a new community service award: the CBS News Bay Area Icon Award. Submit nominations for an outstanding community hero at kpix.com/icon.
It's the most wonderful time of the year for a South Bay woman who has played Mrs. Claus for more than 40 years for the children of North San Jose's Alviso District.
For residents of the Oakland Hills, the prospect of another wildfire always remains a concern. This week's Jefferson Awards winner has made it his mission to make the hills and other high-risk areas safer.
In East Palo Alto -- where state education numbers show more than nine in ten public school students are low income and more than half are English learners -- many are finding hope and connection at the Boys & Girls Clubs of the Peninsula.
This week's Jefferson Award winner is Army veteran who continues to live a life of service into his 80s, by feeding hundreds of San Francisco families a week.
A Bay Area man who overcame tremendous obstacles to excel in school has made it his mission to gear up other students for success in the classroom and in life.
For Students Rising Above scholar Josh Collins it took moving across the country to realize the value of his Bay Area family.
Samir Hooker had to grow up fast after his stepfather was shot dead 12 years ago. Now he is watching over his mom and sister while attending UC Berkeley.
It's hard enough to graduate from one of the most prestigious schools in the country when you're the first in your family to go to college. Imagine doing that while you're also trying to protect your parents from being deported?
Some students who are the first in their families to go to college face the challenge of balancing a rigorous academic load while still working to help support their family back home.